Exposure of Pregnant Mice to Perfluorobutanesulfonate Causes Hypothyroxinemia and Developmental Abnormalities in Female Offspring

Gestational Zearalenone Exposure Causes Reproductive and Developmental Toxicity in Pregnant Rats and Female Offspring

Zearalenone (ZEN) is an oestrogenic mycotoxin commonly found in food and feed products and can affect reproduction and development in both humans and animals. This study aimed to determine the toxic effects of ZEN on maternal SD rats and the F1 female offspring. Sixty-four pregnant rats were divided into 4 groups and exposed to feed contaminated with ZEN (0, 5, 10, and 20 mg/kg feed) on gestati...

Exposure of pregnant rats to cigarette-smoke condensate causes glomerular abnormalities in offspring.

BACKGROUND Higher blood pressure and albuminuria are found in offspring of mothers who smoke during pregnancy. Whether or not kidney development is affected by maternal smoking is unknown. METHODS Sprague-Dawley rats were randomly allocated to twice-daily cigarette smoke and nicotine condensate (1 mg/kg) or vehicle at day 10 of pregnancy until delivery. RESULTS Exposed offspring did not dif...

Baicalein, a flavonoid causes prolonged estrus and suppressed fertility output upon prenatal exposure in female mice

Objective(s): Baicalein (BC), a phytoestrogen of the flavonoid family shows beneficiary and adverse effects. Effect of BC on reproduction is still not understood. Reproductive toxic effects on female mice were tested in this study.Materials and Methods: Inseminated Wistar mice were divided into four groups and administered IP with 30, 60, and 90 mg/Kg body weight of BC on gestation daydays 11, ...

Long-term Developmental Effects of Lactational Exposure to Lead Acetate on Ovary in Offspring Wistar Rats

Chronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice

Diquat is a bipyridyl herbicide that has been widely used as a model chemical for in vivo studies of oxidative stress due to its generation of superoxide anions, and cytotoxic effects. There is little information regarding the toxic effects of diquat on the female reproductive system, particularly ovarian function. Thus, we investigated the reproductive toxic effects of diquat on female mice. C...